Detalhe da pesquisa
1.
Small-molecule IKKß activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Proc Natl Acad Sci U S A
; 119(18): e2115071119, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476515
2.
CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax.
Mol Pharmacol
; 96(4): 419-429, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31467029
3.
Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy.
Bioorg Med Chem Lett
; 28(23-24): 3736-3740, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30343954
4.
Anti-leishmanial and cytotoxic activities of amino acid-triazole hybrids: Synthesis, biological evaluation, molecular docking and in silico physico-chemical properties.
Bioorg Med Chem Lett
; 27(9): 1886-1891, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28359789
5.
Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer.
Cell Rep
; 40(7): 111218, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35977518
6.
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKß phosphorylation for pancreatic cancer therapy.
Eur J Med Chem
; 222: 113579, 2021 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34098465
7.
Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK.
Chem Biol Drug Des
; 96(2): 773-784, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32237047
8.
Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respiratory infection.
Int J Pharm
; 565: 242-257, 2019 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31077762
9.
Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy.
ACS Chem Biol
; 13(5): 1148-1152, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29608269
10.
Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation Protein.
Curr Med Chem
; 24(40): 4488-4514, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28901269
11.
Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors.
ACS Med Chem Lett
; 8(11): 1183-1187, 2017 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29375750
12.
Discovery and characterization of small molecule Rac1 inhibitors.
Oncotarget
; 8(21): 34586-34600, 2017 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28410221
13.
Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).
Chem Commun (Camb)
; 53(54): 7577-7580, 2017 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28636052
14.
Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.
J Med Chem
; 59(19): 8667-8684, 2016 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27171036
15.
Synthesis of diphenylamine-based novel fluorescent styryl colorants by Knoevenagel condensation using a conventional method, biocatalyst, and deep eutectic solvent.
Org Lett
; 12(7): 1456-9, 2010 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20199063